Membrane Protein Solution for Drug Discovery

Membrane proteins consisting of approximately 23% of the human proteome, play a crucial role in many physiological processes. Since most drugs achieve their therapeutic effects by interacting with membrane proteins, these proteins are also the major drug target category for pharmaceuticals (more than 60%). To date, there are some typical membrane protein targets, including GPCRs, transporters and ion channels. Over the past 20 years, new technologies and methods have greatly advanced the discovery and development of membrane protein-based drugs, including small molecule drugs and monoclonal antibody (mAb) therapeutics.

Fig.1 Representative examples of therapeutically-relevant membrane protein structures. (Gulezian, Ellen, et al., 2021)

Membrane proteins as drug targets

According to their structure, membrane proteins can be divided into three types, including integral membrane proteins, peripheral membrane proteins, and lipid-anchored proteins. Among them, integral membrane proteins (including transmembrane proteins) anchored to membranes are important to drug targets across most fields of medicine. Increasing knowledge of functional modulators of integral membrane proteins, such as ligands, specific lipids/cholesterol, protein interaction partners, and nanobodies that stabilize desired conformations, can help select more specific integral membrane protein-targeting drugs in discovery analysis.

Membrane protein-based drug discovery and development

Creative Proteomics is a leading contract research organization (CRO) focused on providing high-quality cell membrane and membrane protein-related services for clients and partners. We specialize in a one-stop shop for membrane protein production through high-quality membrane protein expression, extraction, stabilization and purification. Moreover, based on a wide range of advanced technologies and approaches, such as membrane protein microarray screening, surface plasmon resonance (SPR), mass spectrometry (MS), X-ray crystallography, cryo-electron microscopy (Cryo-EM), and nuclear magnetic resonance (NMR), we can provide reliable and flexible services to accelerate the progress of membrane protein-based drug development. Our flexible and robust platform allows us to work with our clients at every stage of a drug discovery program, from hit discovery and validation to structure-based optimization of preclinical compounds.

Our service support

• Extraction and production of membrane protein
• Identification of membrane protein
• Structural determination of membrane protein
• Interaction analysis of membrane protein with other molecules

Applications of our services

• Small molecule drug discovery and development
• mAb discovery and development

Creative Proteomics specializes in structural and high-throughput screening technologies for membrane protein-based drug discovery. How can we help you? How do I start this service? And how long will it take? If you have any of these questions, please don't hesitate to contact us. Our professional technical staff will contact you as soon as possible and provide you with professional answers.

Explore our services

• Membrane protein identification
• Membrane and membrane protein extraction
• Membrane protein production service
• Membrane protein-molecule interaction analysis
• Membrane protein structure determination
• Membrane proteomics service

Reference

1. Gulezian, Ellen, et al. "Membrane protein production and formulation for drug discovery." Trends in Pharmacological Sciences 42.8 (2021): 657-674.

* For Research Use Only. Not for use in diagnostic procedures.