Exosome in Biopharm
Online InquiryExosomes can be designed to display specific ligands on their surface to target specific cells and can be loaded with different drugs that can be located on the membrane surface or carried within the exosome. Compared to lipid nanoparticles, these intracellular vesicles exhibit lower immunogenicity and significantly reduced toxicity, but with improved drug encapsulation and greater in vivo biodistribution. To further promote the development of exosome-based genes and drug delivery, Creative Proteomics provides a range of customized and inventive services and solutions, including exosome isolation and purification, exosome identification, exosome proteomics analysis, exosome metabolomics analysis and so on.
Comparison of exosomes and liposomes in delivering therapeutic materials
Liposomes are the earliest nanoparticle delivery platform. Liposomes are generally small circular vesicles with hydrophilic nuclei, consisting of one (unilamellar) or more (multilamellar) phospholipid layers that facilitate uptake by cells via endocytosis or endocytosis-like mechanisms. Compared to liposomes and other synthetic nanocarriers, endogenous sources confer a large number of unique properties to exosomes in targeted delivery. However, for the application of exosomes as drug carriers, the endogenous origin may be a double-edged sword.
| Comparison of exosomes and liposomes | |
|---|---|
| The advantages of exosomes in drug delivery versus liposomes | The disadvantages of exosomes in drug delivery versus liposomes |
| Highly biocompatible vesicles | Low production efficiency |
| More stable in the body fluid | Limited efficiency of cargo loading |
| Better targeting capacity | Tougher quality control |
| Have bioactive materials that may be therapeutically | |
We provide the following exosome-based gene and drug delivery solutions, including but not limited to:
Since their discovery, exosomes have been potentially used as drug carriers for various diseases and cancers due to their unique properties such as stability, tumor targeting, and biocompatibility. As natural carriers, exosomes have not only been utilized to deliver RNA and proteins but also for the delivery of therapeutic small molecules. Creative Proteomics proudly offers a range of exosome research and analytical services. Our capability can greatly promote the application of exosomes as carriers for various genes and drug delivery, including
- Exosomes for ASO Delivery
- Exosomes for siRNA Delivery
- Exosomes for miRNA Delivery
- Exosomes for mRNA Delivery
- Exosomes for circRNA Delivery
- Exosomes for Protein Delivery
- Exosomes for Small Molecule Delivery
2. Exosome-based vaccine development
To further promote the development of exosome-based vaccines, Creative Proteomics provides a range of customized and innovative solutions. We are committed to maximizing the potential of exosomes as an important candidate for infectious disease vaccine and cancer vaccine development. We hope to meet our customers' specific requirements for projects at the preclinical stage.
Creative Proteomics is committed to a culture of continuous improvement, innovation, and world-class customer support. For years, based on knowledge and experience in exosome research and analysis, we have been offering sustainable innovative services and solutions at low maintenance costs according to our global customers' needs. Contact us or directly send us an inquiry. We look forward to providing services for your next project.
Reference
- Fu, Shengyang, et al. "Exosome engineering: Current progress in cargo loading and targeted delivery." NanoImpact 20 (2020): 100261.
* For Research Use Only. Not for use in diagnostic procedures.
