Proteomics, the study of proteins and their functions, has evolved into a dynamic field that holds the key to unlocking profound insights into biological systems. Our expertise lies in harnessing the capabilities of DIA technology, a revolutionary approach that enables comprehensive and precise analysis of the proteome. Unlike traditional methods, DIA ensures that no protein is overlooked, providing a panoramic view of protein expression, modifications, and interactions.
Data-Independent Acquisition (DIA) technology operates on a foundational principle that centers around systematically breaking down complex mixtures of proteins and peptides. This fragmentation process is followed by the simultaneous detection of these fragments across a broad mass-to-charge ratio (m/z) range. In contrast to its precursor, Data-Dependent Acquisition (DDA), which selectively analyzes the most abundant peptides, DIA casts a wider net. By doing so, it ensures a more comprehensive coverage of the proteome, encompassing both abundant and low-abundance peptides. This comprehensive approach to analysis is made possible through a two-step process: precursor ion selection and fragment ion detection. In the precursor ion selection step, a range of m/z values is divided into windows, each of which is isolated for subsequent fragmentation. The resulting fragment ion spectra provide a wealth of data, enabling the generation of a holistic dataset that paints a detailed picture of the proteome under investigation.
In the vanguard of proteomics lies Creative Proteomics, we have harnessed the transformative potential of DIA technology to offer a diverse array of specialized proteomic services. These services transcend conventional boundaries, facilitating groundbreaking research across a wide spectrum of applications.
Biomarker Proteomics Solutions: Unlock the potential of biomarkers through comprehensive proteomic analysis, paving the way for precision diagnostics and personalized medicine.
Clinical Proteomics Research Solutions: Dive into diseases at the molecular level, unraveling protein alterations and modifications for innovative diagnostic and therapeutic strategies.
Drug Target Deconvolution: Navigate the intricate landscape of drug targets by systematically profiling protein expression in response to treatments, revolutionizing drug development.
Drug's Mechanism of Action: Illuminate the pathways behind drug action, unraveling dynamic protein networks that underpin therapeutic effects.
HCPs Analysis: Ensure biopharmaceutical safety by thorough analysis of Host Cell Proteins (HCPs), securing the purity of your products.
Microorganisms Proteomic Research: Venture into the microcosm of microorganisms, revealing their physiology and virulence factors for groundbreaking insights.
Microbial Pathogens Research: Combat infectious diseases by characterizing microbial pathogens, advancing our understanding of pathogenic mechanisms.
Genetic Association Study: Unravel the genetic-proteomic nexus, advancing genetic association studies and deepening insights into the interplay between genetics and proteins.
Pathological Study of Disease: Dissect proteomic alterations linked to diverse diseases, uncovering the mechanisms driving pathogenesis and potential therapeutic avenues.
Plant Tissues Quantitative Proteomics: Illuminate plant biology with quantitative insights, propelling advancements in agriculture and environmental understanding.
Exosome Proteomics: Profile exosomes to uncover their cargo and implications in intercellular communication, shaping our understanding of these vital mediators.
lmmunopeptidome Profiling: Delve into immune-related peptides, advancing immunology and vaccine development through a deeper comprehension of immune responses.
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4D Proteomics with Data-Independent Acquisition (DIA)
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×Specializing in proteomics, Creative Proteomics offers cutting-edge protein analysis services. Our distinctive approach revolves around harnessing the power of DIA technology, enabling us to deliver precise and comprehensive insights that drive advancements in research and industry.