Animal venom is a unique natural product, a mixture of protein/peptide and other substances. The analysis of pharmacological and toxicological of the venom components found that it has potential therapeutic effects, such as snake venom, bee venom and scorpion venom, and many animal venoms show excellent anticancer effects. They affect the physiological processes of cancer cells, including cell proliferation and migration, cell apoptosis and the formation of new blood vessels.
Cancer chemotherapy can cause many side effects and result in unsatisfactory therapeutic effects. However, many venom proteins/peptides have been proven to have a good antitumor effect. Specific targeted anticancer agents from venom seem to be a potential tool. Therefore, Creative Proteomics provides customers with services that utilize the natural anti-cancer potential of venom toxins to be applied to cancer targeted therapy.
Cancer is a deadly disease, causing many devastating results to the human body. At present, studies have shown that toxin proteins/peptides of many animal venoms have the highly selective toxicity of a variety of cancer cells, and can exert anticancer effects through different pathways and mechanisms, such as inhibiting cancer cell proliferation, participating in cancer cell apoptosis, and inhibiting new blood vessel formation. Here is some specific information on the use of animal venom to develop anti-cancer drugs.
Animal Venom | Venom Component | Cancer Cell Type | Anti-Cancer Mechanism |
---|---|---|---|
Bee venom | Melittin | Gastric cancer cells | Apoptosis of cancer cells through the mitochondrial pathway |
Wasp venom | Polybia-MPI | Prostate and bladder cancer cells | Pore formation |
Scorpion venom | Chlorotoxin | Pancreatic cancer cells | Inhibition of Cl- conductance that reduces cancer progression |
Snake venom | PLA2 | Microvascular endothelial cells | Anti-angiogenesis effect |
Snake venom | Metalloproteinases | Melanoma cells | Inhibition of cancer cell proliferation and increased apoptosis |
Snake venom | Cytotoxins | Breast cancer cells | Apoptosis through the lysosomal pathway |
In order to meet customers' new drug treatment needs, we can obtain venom toxins with anti-cancer therapeutic potential through separation, extraction and recombinant synthesis. Through genome, transcriptome, proteome/peptide analysis, more ways can be studied to explore the molecular mechanism and target specificity of venom toxins. We specifically provide:
We can prepare customized services according to customer needs, including information consultation, design and implementation of detailed experimental schemes, etc.
Creative Proteomics provides services related to cancer targeted venom therapy research. We have mature venom toxin protein/peptide separation and purification technology and excellent characterization and analysis technology, and we are a service provider you can rely on for the application of venom to cancer treatment research. If you are interested in any direction of venom research, you can contact us.