Creative Proteomics relies on years of experience in proteomics bioinformatics analysis to provide customers with different types of post-translational modification proteomics data analysis services. The post-translational modification proteomics data analysis we provide is suitable for different types of poisonous species or venom research. Such as snakes, scorpions, frogs, venomous lizard, fire-bellied toads, snails, spiders, bees, ants, cone snails, jellyfish, etc.
As a natural animal toxin protein, the venom of poisonous species in nature contains a variety of enzymes, non-enzymatic proteins and other small molecule proteins, and has a wide range of biological activities and pharmacological effects. Venom protein needs to undergo a series of post-translational processing and modification to form the final complex functional executive body-venom. A variety of post-translational modifications (PTM) have been discovered, involving different modified enzyme systems. These post-translational modifications have a certain impact on the structure and function of the venom.
With the maturity of proteomics research technology, post-translational modification proteomics methods are widely used in venom research. Common protein post-translational modification includes Phosphorylation, Disulfide bond, γ-carboxylation, Acetylation, Glycosylation, Ubiquitination, etc. Using bioinformatics methods to analyze the post-translational modification omics data of different venom proteins to detect the modification sites of the target protein. The identification analysis and quantitative analysis of modified proteins of venom provide a data basis for studying the relationship between dynamic changes of venom modified proteome and changes of venom phenotype.
PTMs category | Common Functions |
---|---|
Phosphorylation | Change protein form, activate or deactivate catalytic activity |
Methylation | Affect the composition of proteins and their affinity for other proteins |
Acetylation | Affect protein configuration and its affinity for other proteins |
Ubiquitination | Degradation of target protein |
Glycosylation | Direct the protein to the destination |
The venom protein post-translational modification data analysis services provided by Creative Proteomics, has undergone scientific and meticulous design and strict quality control at every step to ensure high-quality research results. The following figure shows the general pipeline of Creative Proteomics' venom protein post-translational modification bioinformatics data analysis:
Fig 1. Venom protein post-translational modification data analysis pipeline - Creative Proteomics.
In addition to providing general data analysis content, Creative Proteomics also provides customized analysis based on customer needs. Designed to help researchers to mine effective venom protein post-translational modification information to the maximum extent.
Standard analysis content | Raw data processing
Identification of venom protein modified peptides and modified proteins:
Functional analysis of modified proteins:
|
Customized information analysis | The content of customized information analysis can be determined through negotiation based on the customer's data analysis needs. Such as phosphorylation site motif analysis. |
Creative Proteomics, as a rare professional venomics research service provider in the world, relies on its years of bioinformatics data analysis experience to provide customers with one-stop venom protein post-translational modification data analyss services. In addition to bioinformatics data analysis, we also provide venom post-translational modification studies services for researchers. If you have any questions about our service, please feel free to contact us immediately.