Physicochemical Properties Analysis of Venom Peptide/Protein

The diversity of venom protein compounds including peptides, proteins, and enzymes makes these venoms a promising source of molecules with antibacterial, antiviral, and anticancer activities. The main characteristics of these active molecules are lack of disulfide bonds, cationic charge, sequence diversity, hemolytic and antibacterial activity, and relatively low molecular weight. 

The analysis of physical and chemical properties can help the biological analysis of venom peptide/protein, therefore, Creative Proteomics provides corresponding physical and chemical properties analysis services for the research of venom peptides/proteins. After calculation and analysis, the length, molecular weight, total hydrophobic ratio, net charge and other physical and chemical properties of the target peptide/protein are determined. 

Our Services

Venom peptides and proteins in different poisonous animals, such as snakes, scorpions, spiders, bees, wasps, snails, toads, frogs, have specific activities, which makes their physicochemical properties characterization very important. We provide the following characterization analysis services, including but not limited to:

The therapeutic value of venom peptide/protein still has great potential. Creative Proteomics provides preliminary and in-depth experimental services to support research and implement quality control to help clarify the biological characteristics of venom.

Data Analysis

• Use Proteus to examine the secondary structure of the venom peptide and analyze the specific helical structure of the mature area.
• Use IPC to calculate the pl value of venom peptide/protein and judge it to be alkaline or acidic.
• Through the comparison of parameters: hydrophobicity, hydrophobic moment and net charge, it is judged whether the venom peptide/protein has a cationic, amphoteric helical conformation.
• Use HeliQuest to check physical and chemical properties.
• Use Antifp for biological activity prediction.

Delivered Reports

• Experimental steps
• Instrument parameters
• Original data and pictures
• Analysis report

Advantages

Creative Proteomics has rich experience in venom peptide/protein projects and species experience, and our various physical and chemical indicators are also excellent. In terms of venom peptide/protein research, we provide different toxic species (such as snakes, scorpions, frogs, monsters, fire-bellied toads, snails, spiders, bees, ants, cone snails, jellyfish, etc.) to meet the needs of different levels of scientific research.

• Relying on advanced equipment platform and professional analysis team.
• Each step of the inspection has undergone scientific and meticulous design and strict quality control to ensure high-quality research results.
• Customized research solutions and one-stop research services.

As the world's leading professional venomomics research service provider, Creative Proteomics provides customers with one-stop research on the physical and chemical properties of venom peptides/proteins. At the same time, we also provide a series of services of venom peptideomics and proteomics. If you have any questions about our venom peptide/protein physical and chemical properties research service, please feel free to contact us, technical support will reply you as soon as possible. Looking forward to working with you!

Reference

• Naoki,T, et al. Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components. Toxins,2019,11(1).