Sea Anemone Venom Solutions

Many people have such a misunderstanding that sea anemones are not animals but plants. In fact, sea anemones are poisonous animals. Similar to other common poisonous animals, they produce venoms with special molecular diversity. Sea anemone venom is a complex mixture of proteins, peptides and small molecule compounds. The protein toxins that have been fully characterized can be divided into three categories: phospholipase A₂, cytolysin and neurotoxin. The peptide toxins in the sea anemone venom have specific biological activities, such as autoimmunity, analgesia, and central nervous system inhibition. Therefore, sea anemones are a treasure trove of relatively unexplored biological activities and therapeutic compounds.

Creative Proteomics provides sea anemone venom solutions for customer to explore complex sea anemone venom reservoir with a combination of transcriptomics and proteomics methods. We mainly use omics methods and high-throughput bioassays to help customers discover new anemone toxins from anemone resources, which plays an important role in the development of related drugs.

Discovery Service of New Anemone Toxins

Sea anemones are rich in various biologically active peptide toxins, which can be used in neuroscience research tools or drug development. At present, more than 1100 kinds of sea anemones have been reported, but few have been studied. Therefore, it is necessary to find and study peptide toxins in sea anemones more systematically. Creative Proteomics helps researchers or companies discover sea anemone peptide toxins through molecular biology. We offer two strategies: gene cloning and high-throughput sequencing.

Technical Solutions

We provide more effective technical solutions for venom separation and extraction.

We provide efficient, resource-saving, and high-throughput transcriptomics/proteomics combined technical solutions.

We provide a comprehensive technical solution for the structural characterization and toxicological and pharmacological activity characterization of anemone toxins.

• X-ray crystallography technology → obtain high-precision anemone venom protein structure
• NMR → determine the structure of anemone venom small peptides
• Cryo-electron microscopy → determine the structure of anemone venom macromolecular proteins
• Animal experiment → evaluation of lethal activity, analgesic activity, proteolytic activity, phospholipase activity, hemolytic activity, skin necrosis activity and other indicators.

Advantages

• High efficiency, resource saving, high throughput
• Customizable solutions
• Complete sea anemone venom analysis report
• Short submission cycle

Creative Proteomics is committed to the research of sea anemone venom. Based on the advanced facility platform and mature service team, we are confident to complete your sea anemone venom research and provide accurate and effective findings. If you want to know more, please feel free to contact us.

Reference

• Fu J X, et al. Discovery of novel peptide neurotoxins from sea anemone species. Frontiers in Bioscience-Landmark, 2021. 26(11); 1256-1273.