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Domain Enrichment Analysis Service

A domain is the basic building block for a protein structure, although many proteins only contain a single domain. Domains have different functional and structural units in a given protein. Usually they are act as the operational units responsible for a specific function or interaction, contributing to the overall role of a protein. Some of them are also linked to phenotypic traits and diseased states. Domains may exist in various biological contexts, where similar domains can be found in proteins with different functions. For instance, Src homology 3 (SH3) domains are relatively small domains with about 50 amino acid residues involved in protein-protein interactions. These domains have a typical 3D structure and occur in a diverse range of proteins with distinct functions, including phosphatidylinositol 3-kinases, adaptor proteins, phospholipases and myosins.

Enrichment analysis is a widely used and well established technique to test for the statistically significant over-representation of specific groups of genes or proteins, e.g. Pathways. Creative Proteomics can provide multiple enrichment analysis to assist our customers understanding protein functions and gaining the knowledge of biological pathways of interest. Now, bioinformaticians at Creative Proteomics are proud to offer our customers all above enrichment analysis.

The general steps of domain enrichment analysis provided by Creative Proteomics are summarized below:

Calculate a p-value representing the amount to which the proteins in the group are over-represented or under-represented
Evaluate the statistical significance of a node or pathway based on the calculated p-value
Correction for multiple hypothesis testing was carried out using specific method

How to place an order:
How To Place your Order

*If your organization requires signing of a confidentiality agreement, please contact us by email

As one of the leading omics industry company in the word! Creative Proteomics Now is opening to provide Domain Enrichment Analysis service for our customers. With rich experience in the field of bioinformatics, we are willing to provide our customer the most outstanding service to you! Contact Us for all the detailed informations!

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

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Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.

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