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DLS Based Analysis Service

Dynamic light scattering (DLS), which is also known as photon correlation spectroscopy(PCS) or quasi-elastic light scattering(QELS), is an analytical technique, one of the most popular methods used to determine the size of particles, and radius distribution of small particles in suspension or polymers in solution samples.

In the scope of DLS, temporal fluctuations are usually analyzed by the intensity or photon auto-correlation function (ACF). A monochromatic light beam, such as a laser, would be shined onto the tested solutions with spherical particles in Brownian motion, causing Doppler Shift when the light hits the moving particle, changing the wavelength of the original light. The change, is related to the size of the particle. It is possible to compute the sphere size distribution and issue a detailed description of the particle’s motion in the tested medium, measuring the diffusion coefficient of the particle through ACF. Meanwhile, DLS can also be used to probe the behavior of complex fluids such as concentrated polymer solutions.

In practice, DLS can be used to determine the size distribution of various particles including proteins, polymers, micelles, carbohydrates, and nanoparticles. If the system is not disperse in size, the mean effective diameter of the particles can be determined since the measurement depends on not only the size of the particle core, but also the size of surface structures, particle concentration, and the type of ions in the medium.

Generally, as an analytical technique, DLS has the advantages as below:

Accurate, Reliable and Repeatable Particle Size Analysis
Direct Analysis of the Native Samples with Simple or no Sample Preparation
Simple Set-Up and Fully Automated Measurement
Size Measurement of Sizes < 1nm
Size Measurement of Molecules with MW < 1000Da
Low Volume Requirement
Compliance with Regulatory Standards

If necessary, DLS can be utilized to obtain several important parameters of interest, such as molecular weight, radius of gyration, translational diffusion constant and so on. Our experienced analysts and technicians can help you to design and perform the analytical experiments after technical discussion.

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

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