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Structure-based Evolution Analysis of Proteins Service

The extent of divergence in the three-dimensional (3D) structures of homologous proteins in a family is connected with the extent of similarity in these amino acid sequences. It is common knowledge that the 3D structures and structural features of homologous proteins are more conserved than their amino acid sequences. It has been demonstrated many times that the homologous proteins could diverge beyond recognition at the level of their amino acid sequences but maintain similar structure and function. While the relation between sequence divergence and structural divergence in homologous proteins indicate a gross exponential decrease of structural divergence as sequence similarity increases, this relation does not exist at low sequence similarities (below 30%). In some cases of low sequence similarity proteins preserve the fold as well as preserve the broad biochemical features and functional properties, indicating an evolutionary connection. Therefore, structure-based method is a useful way to study protein evolution. Several studies based on the known 3D structures of proteins show that two homologous proteins with insignificant sequence similarity could present a common fold and may perform similar or same biochemical functions. Now, bioinformaticians at Creative Proteomics are proud to tell you we are open to help you with Structure-based Evolution Analysis of Proteins Service!

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As one of the leading omics industry company in the world! Creative Proteomics now is opening to provide structure-based evolution analysis of proteins service for our customers. With rich experience in the field of bioinformatics, we are willing to provide our customer the most outstanding service! Contact us for all the detailed information!

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

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