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COG Annotation Analysis Service

The constantly accelerating speed of microbial genome sequencing keep on ﬂooding public databases with sequences of predicted proteins, only a small portion of which has been ever investigated experimentally or could be studied in detail any time soon. The only feasible way to annotate functions to these proteins is to predict them through bioinformatics analysis. Founded in 1997, the Clusters of Orthologous Groups of proteins (COGs) database has been a widely used tool for functional annotation. The COG database which are classified into 26 functional categories went through several updates, and gradually expanded its genome coverage to 62 organisms involved in 46 bacterial, 13 archaeal and 3 eukaryotic genomes.

The reasons why COG annotation is highly recommended by Creative Proteomics:

COGs depended on the analysis of entire microbial genomes (proteomes), which allowed reliable assignment of paralogs andorthologs for most genes using a simple method based on the search of triangles of bidirectional best hits. This methodenabled both recognition of distant homologs and separation of closely relevant paralogs.
Another important factor was the use of a family-based method whereby the functions of the characterized members of the protein family (COG) was harnessed to assign functions to the complete family and describe the potential functions when there were more than one.
In contrast to the protein domain databases, such as Pfam, SMART or CDD, most entries in the COG database were full-length proteins, which provided a distinct view at the microbial protein content and its evolution.
Finally, the membership of the COGs and the functional annotation were applied for careful manual curation which aimed at assigning biological functions to each COG term while avoiding annotation errors and over predictions

How to place an order:
How To Place your Order

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As one of the leading omics industry company in the world! Creative Proteomics now is opening to provide COG annotation service for our customers. With rich experience in the field of bioinformatics, we are willing to provide our customer the most outstanding service! Contact us for all the detailed informations!

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

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