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Antibiotic Targeted Metabolomics

Antibiotic, is a class of secondary metabolites produced by microorganisms (including bacteria, fungi, and actinomycetes) or higher plants and animals in the course of their lives that have anti-pathogenic or other activities and can interfere with the developmental functions of other living cells chemical substances. Clinically used antibiotics are extracts from microbial cultures and chemically synthesized or semi-synthesized compounds. The antibacterial or bactericidal effect of antibiotics and other antimicrobial agents is mainly aimed at killing the mechanism that "bacteria have and humans (or other plants and animals) do not have", which consists of four major mechanisms of action, namely: inhibition of bacterial cell wall synthesis, enhancement of bacterial cell membrane permeability, interference with bacterial protein synthesis, and inhibition of bacterial nucleic acid replication and transcription.

Antibiotic Targeted Metabolomics Workflow

Substance List

Sulfonamides: 30 species

• Sulfapyridine

• Sulfadoxine

• Sulfathiazole

• Sulfamethizole

• Sulfamethazine

• Sulfadiazine

• Sulfaquinoxaline

• Sulfachloro Pyridazine

• Sulfisomidine

• Sulfadimeth Oxine

• Sulfaguanidine

• Sulfanilamide

• Sulfacetamide

• Sulfamerazine

• Sulfamoxole

• Succinylsulfathiazole

• Sulfamethoxazole

• Sulfamethoxypyridazine

• Sulfamonomethox-Ine

• Sulfisoxazole

• Sulfanitran

• Sulfaclozine

• Sulfameter

• Trimethoprim

• Sulfasalazine

• N-acetylsulfapyridine

• N-acetylsulfadiazine

• N-acetylsulfamethazine

• N-acetylsulfamethoxazole

• N-acetylsulfamerazine

Quinolones: 20 species

• Enrofloxacin

• Danofloxacin

• Difloxacin

• Enoxacin

• Lomefloxacin

• Norfloxacin

• Ofloxacin

• Pefloxacin

• Sarafloxacin

• Sparfloxacin

• Cinoxacin

• Moxifloxacin

• Flumequine

• Pipemidic Acid

• Nalidixic Acid

• Fleroxacin

• Oxolinic Acid

• Piromidic Acid

Tetracyclines: 6 species

• Oxytetracycline

• Tetracycline

• Chlortetracycline

• Minocycline

• Methacycline

Macrolides:16 species

• Roxithromycin

• Tilmicosin

• Ormetoprim

• Oleandomycin

• Azithromycin

• Virginiamycin Ml

• Virginiamycin Sl

• Kitasamycin

• Spiramycin

• Tylosin

• Midecamycin

β-lactams:14 species

• Cefalexin

• Cefradine

• Ampicillin

• Amoxicillin

• Dicloxacillin

• Cioxacillin

• Penicillin V

• Cefapirin

• Piperacillin

• Ceftiofiir

• Penicillin G

Other 3 species

• Thiamphenicol

• Florfenicol

Technical Advantages

1. High throughput: qualitative and quantitative analysis of multiple antibiotics at one time.

2. Accurate quantification and good reproducibility.

3. High sensitivity and low detection limit.

4. Strict quality control system.

5. Good service system.

Antibiotic Targeted Metabolomics Application

Drug Discovery

Drug Efficacy Studies

Drug Toxicology Evaluation

Antibiotic Detection In Food

Metabolomics Sample Submission Guidelines

Download our Metabolomics Sample Preparation Guide for essential instructions on proper sample collection, storage, and transport for optimal experimental results. The guide covers various sample types, including tissues, serum, urine, and cells, along with quantity requirements for untargeted and targeted metabolomics.

Download

Metabolomics Sample Submission Guidelines

* For Research Use Only. Not for use in diagnostic procedures.

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From Our Clients

"I recently used their proteomics service for a project analyzing protein interactions in yeast models. The team was very responsive and helped clarify the methodology they employed, which made me feel confident in the results. The data quality was solid, with clear identification of several key proteins involved in our study. Their thorough analysis enabled me to pinpoint specific interactions that I hadn't considered before, which significantly improved the direction of my research. I appreciate their professionalism and support throughout the process."

Sarah Thompson, University of California, Berkeley

"Our lab collaborated with them on a project studying cancer biomarkers. The proteomics analysis provided was detailed and focused, specifically highlighting the differential expression of proteins between healthy and tumor samples. Their clear explanations of the data helped my team understand the biological implications. I also appreciated their willingness to revise the reports based on our feedback, ensuring that we had everything we needed for our publication. This collaborative spirit was invaluable."

Emily Rodriguez, Stanford University

"Our lab worked with them on a project studying the effects of diet on gut microbiota using proteomics. They used a label-free quantification method to analyze proteins in fecal samples before and after dietary intervention. The results showed significant changes in protein expression linked to microbial activity. This was pivotal for our hypothesis about diet-microbiota interactions. The clarity of their data presentation made it easy for our team to integrate these findings into our ongoing research."

Dr. Lisa Wong, University of Toronto

"My experience with Creative Proteomics during the mass spectrometry analysis was excellent. We sent in human saliva and mouse brain tissue samples, which they expertly analyzed using both LC-MS and GC-MS techniques. The results were invaluable, revealing key metabolites in the saliva and identifying biomarkers linked to brain function in the brain tissue."

Dr. Emily Carter, Senior Research Scientist

"The overall service from Creative Proteomics was outstanding. They made the entire process seamless and efficient, allowing us to focus on our research. We worked with leaf and root samples from various Arabidopsis genotypes for targeted metabolomics analysis. Their thorough profiling of primary and secondary metabolites gave us important insights into how the plants respond metabolically to environmental stress."

Dr. Laura Henderson, Plant Physiologist

"We had a pleasant collaboration with Creative Proteomics on mass spectrometry analysis of lipids. They conducted a detailed analysis of lipid species, providing us with important insights into lipid metabolism and its relationship with metabolic syndrome disease states."

Dr. Sarah Mitchell, Research Scientist

Online Inquiry

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