Identification of Peptide Biomarkers Service
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Service Details
A biomarker is a characteristic that can be measured and evaluated as an indicator of normal biological processes, pathological processes, or pharmacological responses to therapeutic interventions. It can explore the pathogenesis at the molecular level, but also has unique advantages in accurately and sensitively evaluating early and low-level damage, which can provide early warning and provide clinicians with a basis for auxiliary diagnosis to a large extent. As a terminal substitute, biomarkers are helpful for the research and development of target drugs. Interestingly, peptides are ideal biomarker candidates due to their multiple involvement in biological systems, which can migrate between various parts of the organism, so many pathogenic processes can be reflected by the characteristics and pathological changes of the polypeptide composition in different body fluids, and the changes in the abundance of polypeptides related to various diseases can be detected.
Fig. 1. Overview of the workflow of MS-based proteomics/peptidomics for biomarker discovery. (Wei X, et al., 2009)
The discovery of biomarkers can help greatly facilitate the interpretation of clinical trial results. Creative Proteomics develops and validates biomarker assays according to FDA/EMA guidelines to minimize technical variability and ensure maximum reproducibility. Thanks to our high-sensitivity detection mass spectrometry, we provide high-quality peptide biomarker identification services to customers around the world.
Here, our lab technicians offer two common modes of peptide biomarker development: pattern recognition and single/polybiomarker assays.
Creative Proteomics have developed a complete workflow for mass spectrometry-based peptidomic biomarker discovery.
Our peptide biomarker identification service performs two steps simultaneously: identifying the peptides present in a sample (qualitative) and determining the corresponding concentrations (quantitative). Our expert team screens the best candidate peptides for customers by combining the two. Throughout the analysis process, mass spectrometry technology with high resolution, high sensitivity, high throughput and quantitative functions is combined with liquid chromatography (such as UPLC and nano-LC) to provide the most accurate analysis results.
Our peptide biomarker identification service offers the following tests according to validated guidelines, including but not limited to.
Creative Proteomics is a trusted provider of proteomics analysis services. Thanks to our outstanding scientists and powerful mass spectrometry platform, we offer comprehensive and high-quality identification of peptide biomarkers service for global customers. If you have any questions or specific requirements, please feel free to contact us. We will fulfill your goal.
References
For research use only, not intended for any clinical use.