Glycoprotein Structure Analysis Services
- Home
- Applications
- Proteomics Analysis Services
- Glycoproteomics Analysis Services
- Glycoprotein Analysis Services
- Glycoprotein Structure Analysis Services
Service Details
Protein glycosylation is a functionally important but very complex type of post-translational modification. Therefore, comprehensive characterization of glycan structures and their site-specific locations on proteins at the proteomic scale remains an experimental challenge. Glycosylation, an essential post-translational modification of proteins, plays a role in a variety of biological processes such as controlling protein folding, regulating immune responses, and mediating interactions between host cells and enzymes, antibodies, receptors, and various pathogens. Glycosylation, which is typically low in abundance in biological systems, exhibits dynamic changes not only in the size and composition of glycan chains, but also in sialylated linkages. Mass spectrometry is a high-throughput method and provides a useful tool to decipher these dynamically changing structural details to understand the function of protein glycosylation.
Fig. 1. A schematic overview of experimental approaches for the systematic characterization of glycoproteins by mass spectrometry-based proteomic analysis. (Ruiz-May E, et al., 2012)
Glycoproteins are trypsinized to produce aglycosylated peptides and glycopeptides. Glycopeptides, deglycosylated or aglycosylated peptides targeting glycoproteins can be analyzed by MS. To support glycoprotein engineering researchers, Creative Proteomics offers mass spectrometry platform-based technologies to analyze glycoprotein structure.
Creative Proteomics provides the following glycoprotein structure analysis services but not limited to.
*Note: We also offer custom analysis services. For special requirements, please contact us for project discussion.
Creative Proteomics is a trusted provider of glycoproteomics analysis services. We offer a range of glycoprotein structure analysis services to our clients worldwile. Our services guarantee accurate and reliable results, at quick turnaround time! If you would like more information about specific aspects of our services, feel free to contact us and we will be happy to answer any questions.
References
For research use only, not intended for any clinical use.