Acetylated Protein Analysis Service
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Service Details
Acetylation is a broad post-translational modification that is involved in many cellular processes and plays a very important role in the activation of transcriptional regulators in the nucleus. In cells, the reaction of acetylation modification is catalyzed by acetyltransferase, and the acetyl group provided by the metabolite acetyl-CoA can be co- or post-translationally attached to the α-amino group of the N-terminal of the protein or the ε-amino group of the lysine residue. Metabolites such as acetyl-CoA can in turn regulate the degree of acylation modification of proteins, thereby affecting the metabolic function of organisms. It is a type of post-translational modification shared by prokaryotes and eukaryotes. Currently, thousands of acetylated proteins have been identified in proteomic studies. The study of new protein acetylation sites and acetylation modification omics can provide important guidance for revealing the causes of more diseases, and open new ideas for the development of new drugs related to diseases.
Fig. 1. Dynamic acetylation and deacetylation of proteins. (Roux P P, et al., 2013)
Creative Proteomics is a leading global provider of protein sequencing, and our laboratory laboratories are equipped with state-of-the-art tandem mass spectrometers capable of acquiring high-resolution, accurate-mass (HRAM) data.
At Creative Proteomics, we introduce a quantitative proteomic analysis platform for acetylation to analyze acetylation in multiple samples and in eukaryotes and prokaryotes. Before mass spectrometry analysis, our professional and rich laboratory technicians use peptide pre-separation to reduce the impact of high-abundance histones on protein acetylation identification, and then combined with co-immunoprecipitation to enrich acetylated peptides through efficient antibodies, so as to realize the identification and quantification of large-scale acetylation.
In addition different enzymes are used to digest the protein samples during the digestion process, which ensures that peptides with acetylation sites are ionized into mass spectrometry for analysis with high efficiency, eliminating the loss of acetylation information caused by inappropriate peptide lengths and low ionization efficiency.
With cutting-edge equipment and expertise in protein sequencing and mass spectrometry, we provide one-stop acetylated protein analysis service. You only need to tell us the purpose of your experiment and send your samples to us, we will take care of all the follow-up matters of the project.
Creative Proteomics has a experienced scientists team in acetylated protein analysis, we can provide but not limited to:
Our analytical services strictly follow ICH Q6B guidelines with the following attractive features.
Thanks to our powerful mass spectrometry sequencing platform, Creative Proteomics provides a one-stop acetylated protein analysis service. Our experienced scientists work with you to develop tailor-made analytical solutions. Please feel free to contact us with any questions regarding acetylated protein analysis.
References
For research use only, not intended for any clinical use.