Body Fluid Proteomics
Body fluid proteomics is a field of study that focuses on analyzing the protein content of various biological fluids in the human body. It aims to identify and quantify proteins present in these fluids to gain insights into their roles in physiological and pathological processes. With rich experience, Creative Proteomics offers high-quality body fluid proteomics services, providing valuable insights into your protein research.
What is Body Fluid Proteomics
Body fluid proteomics explores the diverse array of proteins present in various bodily fluids, offering a non-invasive window into the physiological state of an organism. Analyzing proteins in fluids such as blood, urine, cerebrospinal fluid, and saliva provides valuable information about health, disease, and systemic responses. Body fluid proteomics has emerged as a dynamic field with broad applications in clinical diagnostics, biomarker discovery, and understanding the molecular basis of various conditions.
Fig.1 Schematic of body fluid proteomics (Bader, J. M., et al. 2023)
Advancements in mass spectrometry, liquid chromatography, and high-throughput technologies have revolutionized the landscape of body fluid proteomics. Researchers can now profile and quantify proteins in complex fluid matrices with remarkable sensitivity and specificity. This has led to the identification of numerous biomarkers associated with diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. The integration of multi-omics approaches further enhances the comprehensive analysis of body fluid proteomes.
Applications of Body Fluid Proteomics
Disease Biomarker Discovery
Body fluid proteomics plays a pivotal role in the discovery of biomarkers indicative of various diseases, ranging from cancers to neurodegenerative disorders. Identifying specific protein signatures in body fluids can enable early disease detection and monitoring.
Personalized Medicine
The analysis of body fluid proteomics contributes to the realization of personalized medicine by uncovering individualized protein profiles. This information can guide clinicians in tailoring treatment strategies based on the unique molecular characteristics of each patient.
Dynamic Nature of Proteins
Body fluids, being dynamic and responsive to physiological changes, offer a real-time snapshot of the body's condition. Proteomic studies in body fluids provide valuable information on the alterations in protein expression associated with disease progression, response to therapy, and recovery.
Liquid Biopsy Applications
Liquid biopsy, a non-invasive sampling of body fluids for molecular analysis, has gained prominence in cancer research. Body fluid proteomics contributes to the identification of circulating tumor markers, paving the way for early cancer detection and monitoring treatment response.
Our Service
With advanced protein detection technology, Creative Proteomics provides targeted solutions for researchers and scientists to help them utilize powerful analytical techniques to reveal the complexity of the proteome. With our thoughtful and detailed services, you can choose any protein analysis, including qualitative, quantitative, targeted and PTM analysis, and we will provide you with a detailed plan according to your requirements. The body fluid proteomics service process is as follows:
Fig.2 Body fluid proteomics workflow
- Sample Preparation
Obtaining a body fluid sample from an organism is the basis of this analysis, and the body fluid sample needs to be well preserved and protected from contamination prior to analysis. - Extraction
Separating and extracting proteins from body fluid is essential for body fluid proteomics, and it is essential to remove high-abundance proteins in order to more comprehensively examine the body fluid proteome. - Detection
WB, protein microarrays and LC-MS/MS are powerful tools for the identification and quantification of peptides, and they provide detection information that facilitates a comprehensive analysis of the body fluid proteome. - Bioinformatics Analysis
The raw mass spectrometry data undergoes bioinformatics analysis to identify proteins, quantify their abundance, and infer potential functional roles. - Result Delivery
After professional data analysis, we deliver results quickly and consistently.
Creative Proteomics brings a wealth of experience to the field of protein research. Our comprehensive services and products cover the entire spectrum of utilizing suitable and efficient gateways. Utilizing our proprietary platform, we have successfully implemented many proteomics research projects. If you are interested, please contact us for more information and a quote.
Reference
- Bader, J. M.; et al. MS-Based Proteomics of Body Fluids: The End of the Beginning. Molecular & Cellular Proteomics. 2023, 22(7): 100577