Proteomics Analysis of Post Translational Modification

About the Brochures

Post-translational modifications (PTMs) play crucial roles in numerous cellular processes, encompassing cell division, signaling, regulatory mechanisms, protein interactions, and gene expression. With over 400 identified types of PTMs, including phosphorylation, acetylation, ubiquitination, methylation, and glycosylation, the study of these modifications poses significant challenges due to their low expression levels within the entire proteome and wide dynamic range in samples.

Creative Proteomics is at the forefront of proteomic research and offers comprehensive analysis services for post-translational modifications. Equipped with an advanced LC-MS/MS platform, Creative Proteomics excels in identifying and quantifying protein PTM sites at both the purified protein and whole proteome levels.

You may be interested in:

• Phosphorylation:

Amino Acid Loci: Ser/Thr/Tyr

Enrichment Methods: IMAC (immobilized metal ion affinity chromatography), TiO2

• Methylation:

Amino Acid Loci: Lys/Arg

Enrichment Methods: Motif-specific antibody

• Acetylation:

Amino Acid Loci: Lys

Enrichment Methods: Motif-specific antibody

• Ubiquitination:

Amino Acid Loci: Lys

Enrichment Methods: Motif-specific antibody

• Glycosylation:

Amino Acid Loci:

    N-Glycosylation: Asn

    O-Glycosylation: Ser/Thr

Enrichment Methods: HILIC (Hydrophilic Interaction Liquid Chromatography)